214831-33-1Relevant academic research and scientific papers
A Simple and Efficient Synthesis of Fused Benzo[ b ]thiophene Derivatives
Ulyankin, Evgeny B.,Kostyuchenko, Anastasia S.,Chernenko, Sergey A.,Bystrushkin, Mikhail O.,Samsonenko, Anna L.,Shatsauskas, Anton L.,Fisyuk, Alexander S.
, p. 2422 - 2434 (2021/04/21)
A new approach to the synthesis of fused benzothiophene derivatives was developed based on iodine-promoted photocyclization of 4,5-diaryl-substituted thiophenes obtained in three steps from commercially available compounds. Comparative analysis showed that photochemical cyclization is a more efficient method for the preparation of fused benzo[ b ]thiophene derivatives, compared to oxidative coupling of 4,5-diaryl-substituted thiophenes in the presence of iron(III) chloride and palladium-catalyzed intramolecular arylation. This new approach provides an efficient synthesis of functionally substituted naphtho[2,1- b:3,4- b ′]dithiophenes, phenanthro[9,10- b ]thiophenes, benzo[1,2- b:3,4- b ′:6,5- b ′′]trithiophenes, as well as new fused heterocycles containing a pyridine ring and/or a carbazole moiety.
A simple and efficient synthesis of substituted 2,2′-bithiophene and 2,2′:5′,2″-terthiophene
Kostyuchenko, Anastasia S.,Averkov, Alexey M.,Fisyuk, Alexander S.
supporting information, p. 1833 - 1835 (2014/05/06)
A simple and efficient approach is developed for the synthesis of substituted 2,2′-bithiophene- and 2,2′:5′,2″- terthiophene-5-carboxylic acids and esters which is based on thiophene ring closure in the Fiesselmann reaction. Using this method, derivatives containing a long alkyl chain with or without an end functional group or an aryl substituent can be conveniently prepared.
5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase
Perner, Richard J.,Gu, Yu-Gui,Lee, Chih-Hung,Bayburt, Erol K.,McKie, Jeffery,Alexander, Karen M.,Kohlhaas, Kathy L.,Wismer, Carol T.,Mikusa, Joe,Jarvis, Michael F.,Kowaluk, Elizabeth A.,Bhagwat, Shripad S.
, p. 5249 - 5257 (2007/10/03)
The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.
5,6,7-trisubstituted-4-aminopyrido[2,3-D] pyrimidine compounds
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, (2008/06/13)
A compound having the formula wherein R1, R2, R3, R4 and R5 are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above i
