3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Base Information

Chemical Name:3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine
CAS No.:99604-73-6
Molecular Formula:C₁₈H₁₇BrN₂O₄
Molecular Weight:405.248
Hs Code.:

Synonyms:3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

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Chemical Property of 3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Chemical Property:

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Technology Process of 3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

There total 5 articles about 3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99604-72-5
5-Acetylamino-6-(2-benzenesulfinyl-acetyl)-4-(2-bromo-phenyl)-3-methyl-pyridine-2-carboxylic acid methyl ester

: 99604-73-6
3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Guidance literature:: With aluminium amalgam; In tetrahydrofuran; water; at -15 - -10 ℃; for 0.25h; Yield given;
DOI:10.1021/jo00350a070

Reference yield:

: 92611-31-9
3-amino-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

: 99604-73-6
3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / potassiumcarbonate / tetrahydrofuran / 22 h / 50 °C

2: 98 percent / sodium hydride / tetrahydrofuran / 4 h / Heating

3: 100 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 0 °C

4: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 40 min

5: aluminum amalgam / tetrahydrofuran; H₂O / 0.25 h / -15 - -10 °C

With aluminium amalgam; sodium hydride; potassium carbonate; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo00350a070

Reference yield:

: 99604-71-4
8-(2-bromophenyl)-2,7-dimethyl-6-(methoxycarbonyl)-4-oxopyridyl<3,2-d>-1,3-oxazine

: 99604-73-6
3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 40 min

2: aluminum amalgam / tetrahydrofuran; H₂O / 0.25 h / -15 - -10 °C

With aluminium amalgam; lithium diisopropyl amide; In tetrahydrofuran; water;
DOI:10.1021/jo00350a070