2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Base Information

Chemical Name:2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine
CAS No.:99573-32-7
Molecular Formula:C₁₆H₁₅BrN₂O₃
Molecular Weight:363.211
Hs Code.:

Synonyms:2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Suppliers and Price of 2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

There total 6 articles about 2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 99604-73-6
3-acetamido-2-acetyl-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

: 99573-32-7
2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 6h;
DOI:10.1021/jo00350a070

Reference yield:

: 92611-31-9
3-amino-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

: 99573-32-7
2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / potassiumcarbonate / tetrahydrofuran / 22 h / 50 °C

2: 98 percent / sodium hydride / tetrahydrofuran / 4 h / Heating

3: 100 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 0 °C

4: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 40 min

5: aluminum amalgam / tetrahydrofuran; H₂O / 0.25 h / -15 - -10 °C

6: 76 percent / 10percent HCl / methanol / 6 h / 60 °C

With hydrogenchloride; aluminium amalgam; sodium hydride; potassium carbonate; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00350a070

Reference yield:

: 99604-71-4
8-(2-bromophenyl)-2,7-dimethyl-6-(methoxycarbonyl)-4-oxopyridyl<3,2-d>-1,3-oxazine

: 99573-32-7
2-acetyl-3-amino-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 40 min

2: aluminum amalgam / tetrahydrofuran; H₂O / 0.25 h / -15 - -10 °C

3: 76 percent / 10percent HCl / methanol / 6 h / 60 °C

With hydrogenchloride; aluminium amalgam; lithium diisopropyl amide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo00350a070