(3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

Base Information

Chemical Name:(3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid
CAS No.:410081-20-8
Molecular Formula:C₂₈H₃₉NO₉
Molecular Weight:533.619
Hs Code.:

Synonyms:(3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

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Chemical Property of (3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

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Technology Process of (3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

There total 2 articles about (3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(1R,2R,3R)-2,3-Bis-(4-methoxy-benzyloxy)-1-methoxymethyl-4-oxo-butyl]-methyl-carbamic acid tert-butyl ester

: 410081-20-8
(3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide; In water; acetonitrile; for 12h;
DOI:10.1139/v01-133

Reference yield:

: 410081-19-5
(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

: 410081-20-8
(3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: OsO₄; N-methylmorpholine-N-oxide / H₂O; 2-methyl-propan-2-ol; acetone / 16 h

1.2: NaIO₄ / methanol; H₂O / 0.33 h

2.1: 4.26 g / NaH₂PO₄*H₂O; 27 percent H₂O₂; NaClO₂ / acetonitrile; H₂O / 12 h

With sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; dihydrogen peroxide; 4-methylmorpholine N-oxide; In water; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1139/v01-133

Reference yield: 72.0%

: 144681-92-5
methyl 2-(4-amino-(2R)-butyl)-4-oxazolecarboxylate

: 410081-20-8
(3R,4R,5R)-4-(N-tert-butyloxycarbonyl)-N-methylamino-5-methoxy-2,3-di(4-methoxybenzyl)oxyhexanoic acid

: 410081-27-5
(2R,3R,4R)-4-(N-(tert-butyloxy)carbonyl-N-methyl)amino-2,3-di(4-methoxybenzyl)oxy-5-methoxy-N-(3R-((4-methoxycarbonyl)-2-oxazolyl)-1-butyl)pentamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 10h;
DOI:10.1139/v01-133