(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

Base Information

Chemical Name:(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene
CAS No.:410081-19-5
Molecular Formula:C₂₉H₄₁NO₇
Molecular Weight:515.647
Hs Code.:

Synonyms:(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

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Chemical Property of (3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

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Technology Process of (3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

There total 1 articles about (3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 410081-18-4
(2R,3R,4S)-2-(tert-butyloxycarbonyl)amino-3,4-di(4-methoxybenzyl)oxy-5-hexen-1-ol

: 74-88-4
methyl iodide

: 410081-19-5
(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 28h;
DOI:10.1139/v01-133

Reference yield:

: 410081-19-5
(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

: [(1R,2R,3R)-2,3-Bis-(4-methoxy-benzyloxy)-1-methoxymethyl-4-oxo-butyl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: (3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; tert-butyl alcohol; for 16h;

With sodium periodate; In methanol; water; for 0.333333h;
DOI:10.1139/v01-133

Reference yield:

: 410081-19-5
(3S,4R,5R)-5-(N-tert-butyloxycarbonyl)-N-methylamino-6-methoxy-3,4-di(4-methoxybenzyl)oxy-1-hexene

: 410081-27-5
(2R,3R,4R)-4-(N-(tert-butyloxy)carbonyl-N-methyl)amino-2,3-di(4-methoxybenzyl)oxy-5-methoxy-N-(3R-((4-methoxycarbonyl)-2-oxazolyl)-1-butyl)pentamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: OsO₄; N-methylmorpholine-N-oxide / H₂O; 2-methyl-propan-2-ol; acetone / 16 h

1.2: NaIO₄ / methanol; H₂O / 0.33 h

2.1: 4.26 g / NaH₂PO₄*H₂O; 27 percent H₂O₂; NaClO₂ / acetonitrile; H₂O / 12 h

3.1: 72 percent / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / dimethylformamide / 10 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; dihydrogen peroxide; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1139/v01-133