3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

Base Information

Chemical Name:3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester
CAS No.:1026369-72-1
Molecular Formula:C₁₆H₂₀Cl₂N₂O₅S₂
Molecular Weight:455.383
Hs Code.:

Synonyms:3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

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Chemical Property of 3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

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Technology Process of 3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

There total 5 articles about 3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151-50-8
potassium cyanide

: 4-[4-(2,4-Dichloro-benzenesulfonylamino)-butylsulfanyl]-3-oxo-butyric acid methyl ester

: 1026369-72-1
3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

Guidance literature:: With potassium dihydrogenphosphate; In diethyl ether; at 0 ℃; for 18h;
DOI:10.1021/jm960167w

Reference yield:

: 16271-33-3
2,4-Dichlorobenzenesulfonyl chloride

: 1026369-72-1
3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 27 percent / pyridine / 36 h / Ambient temperature

2: N-bromosuccinimide, Ph₃P / CH₂Cl₂ / 0.42 h / 0 - 20 °C

3: dimethylformamide / 2 h / 4A molecular sieves

4: 1.) NaOMe / 1.) MeOH, 10 min, 2.) MeOH, RT, 18 h

5: aq. KH₂PO₄ / diethyl ether / 18 h / 0 °C

With pyridine; potassium dihydrogenphosphate; N-Bromosuccinimide; sodium methylate; triphenylphosphine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960167w

Reference yield:

: N-(4-Bromo-butyl)-2,4-dichloro-benzenesulfonamide

: 1026369-72-1
3-Cyano-4-[4-(2,4-dichloro-benzenesulfonylamino)-butylsulfanyl]-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 2 h / 4A molecular sieves

2: 1.) NaOMe / 1.) MeOH, 10 min, 2.) MeOH, RT, 18 h

3: aq. KH₂PO₄ / diethyl ether / 18 h / 0 °C

With potassium dihydrogenphosphate; sodium methylate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm960167w