3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

Base Information

Chemical Name:3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine
CAS No.:361456-04-4
Molecular Formula:C₁₉H₂₄N₂O₂Si
Molecular Weight:340.497
Hs Code.:

3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1<i>H</i>-pyrrolo[3,2-<i>b</i>]pyridine

Synonyms:3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

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Chemical Property of 3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

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Technology Process of 3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

There total 6 articles about 3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5720-07-0
4-methoxyphenylboronic acid

: 361456-02-2
3-iodo-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

: 361456-04-4
3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; for 3h; Heating;
DOI:10.1016/S0960-894X(01)00022-1

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 361456-04-4
3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / t-BuOK / dimethylformamide / 20 °C

2: 87 percent / t-BuOK / tetrahydrofuran / 3 h / -10 °C

3: 76 percent / H₂ / Pd/C / ethanol

4: 100 percent / NIS / tetrahydrofuran / 2 h / 20 °C

5: 71 percent / PdCl₂(dppf); 2 N aq. Na₂CO₃ / ethanol / 3 h / Heating

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; potassium tert-butylate; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 5: Suzuki cross-coupling reaction;
DOI:10.1016/S0960-894X(01)00022-1

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 361456-04-4
3-(4-methoxy-phenyl)-5-(2-trimethylsilanyl-ethoxy)-1H-pyrrolo[3,2-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / t-BuOK / dimethylformamide / 20 °C

2: 87 percent / t-BuOK / tetrahydrofuran / 3 h / -10 °C

3: 76 percent / H₂ / Pd/C / ethanol

4: 100 percent / NIS / tetrahydrofuran / 2 h / 20 °C

5: 71 percent / PdCl₂(dppf); 2 N aq. Na₂CO₃ / ethanol / 3 h / Heating

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; potassium tert-butylate; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 5: Suzuki cross-coupling reaction;
DOI:10.1016/S0960-894X(01)00022-1