N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide

Base Information

Chemical Name:N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide
CAS No.:730981-25-6
Molecular Formula:C₉H₁₄N₂O₃S
Molecular Weight:230.288
Hs Code.:
DSSTox Substance ID:DTXSID901189046

Synonyms:DTXSID901189046;N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide;730981-25-6

Suppliers and Price of N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide

Chemical Property:

XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:230.07251349
Heavy Atom Count:15
Complexity:286

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CS(=O)(=O)NC1=CC=CC(=C1)C(CN)O
Isomeric SMILES:CS(=O)(=O)NC1=CC=CC(=C1)[C@H](CN)O

Technology Process of N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide

There total 6 articles about N-[3-[(1R)-2-amino-1-hydroxyethyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 730981-22-3
[2-hydroxy-2-(3-methanesulfonylamino-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 730981-25-6
N-[3-(2-amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(01)00063-4

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 730981-25-6
N-[3-(2-amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / (R)-2-methyl-CBS-oxazaborolidine; BH₃ / tetrahydrofuran

2: 70 percent / NH₃ / methanol

3: 78 percent / dimethylformamide

4: 83 percent / Fe; aq. NH₄Cl / methanol

5: 49 percent / pyridine / CH₂Cl₂

6: 64 percent / TFA / CH₂Cl₂

With pyridine; borane; ammonia; iron; ammonium chloride; trifluoroacetic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00063-4

Reference yield:

: 129894-60-6
(R)-2-Amino-1-(3-nitro-phenyl)-ethanol

: 730981-25-6
N-[3-(2-amino-1-hydroxy-ethyl)-phenyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / dimethylformamide

2: 83 percent / Fe; aq. NH₄Cl / methanol

3: 49 percent / pyridine / CH₂Cl₂

4: 64 percent / TFA / CH₂Cl₂

With pyridine; iron; ammonium chloride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00063-4