tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

Base Information

Chemical Name:tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate
CAS No.:729612-85-5
Molecular Formula:C₁₉H₂₃FN₂O₅S
Molecular Weight:410.466
Hs Code.:

Synonyms:tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

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Technology Process of tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

There total 1 articles about tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 103360-04-9
4-fluorobenzylsulfonyl chloride

: 179524-34-6
t-Butyl (3-Amino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetate

: 729612-85-5
tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

Guidance literature:: With triethylamine; In dichloromethane; for 2h;
DOI:10.1016/j.ejmech.2005.03.007

Reference yield: 94.0%

: 729612-85-5
tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

: 729612-88-8
2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2005.03.007

Reference yield:

: 729612-85-5
tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate

: 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / HCl / ethyl acetate / 1 h / 20 °C

2: 27 percent / N-methylmorpholine; 1-hydroxybenzotriazole; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 12 h / 20 °C / pH 8

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2005.03.007