N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

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Chemical Name:N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide
CAS No.:166194-11-2
Molecular Formula:C₄₀H₄₃N₅O₆Si
Molecular Weight:717.897
Hs Code.:

Synonyms:N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

There total 3 articles about N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 166194-11-2
N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / imidazole / dimethylformamide / Ambient temperature

2: 1.) n-BuLi / 1.) THF, -78 deg C, 75 min, 2.) THF, from -78 deg C to RT, 2 h 20 min

3: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to 0 deg C, 4.25 h

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1021/jm00014a023

Reference yield:

: 166194-08-7
methyl 3-<(tert-butyldiphenylsilyl)oxy>propionate

: 166194-11-2
N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 75 min, 2.) THF, from -78 deg C to RT, 2 h 20 min

2: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to 0 deg C, 4.25 h

With n-butyllithium;
DOI:10.1021/jm00014a023

Reference yield:

: 43077-06-1
6-N-benzoyl-2',3'-O-isopropylideneadenosine-5'-aldehyde

: 166193-95-9
4-<(tert-butyldiphenylsilyl)oxy>-1-(dimethoxyphosphinyl)-2-oxobutane

: 166194-11-2
N-(9-{(3aR,4R,6R,6aR)-6-[(Z)-5-(tert-Butyl-diphenyl-silanyloxy)-3-oxo-pent-1-enyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to 0 deg C, 4.25 h;
DOI:10.1021/jm00014a023