(4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester

Base Information

• Chemical Name: (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester
• CAS No.: 350584-51-9
• Molecular Formula: C₃₄H₅₂N₅O₈P
• Molecular Weight: 689.789
• Mol file: 350584-51-9.mol

Synonyms:(4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester

Chemical Property of (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester

There total 4 articles about (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-N1-prop-2-ynyl-succinamide (350584-50-8) + 1-{2-acetylamino-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-cyclohexanecarboxylic acid methyl ester → (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester (350584-51-9)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/S0960-894X(01)00173-1

Reference yield:

di-tert-butyl phosphite (13086-84-5) → (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester (350584-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 20 °C

2: EDC; HOBt; NMM / dimethylformamide / 20 °C

With 4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00173-1

Reference yield:

1-[(S)-2-Acetylamino-3-(4-chloromethyl-phenyl)-propionylamino]-cyclohexanecarboxylic acid methyl ester (221303-31-7) → (4-{(S)-2-Acetylamino-2-[1-((S)-2-carbamoyl-1-prop-2-ynylcarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-benzyl)-phosphonic acid di-tert-butyl ester (350584-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 20 °C

2: EDC; HOBt; NMM / dimethylformamide / 20 °C

With 4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00173-1

upstream raw materials:

2-amino-N¹-prop-2-ynyl-succinamide

di-tert-butyl phosphite

1-[(S)-2-Acetylamino-3-(4-chloromethyl-phenyl)-propionylamino]-cyclohexanecarboxylic acid methyl ester

Downstream raw materials:

[4-((S)-2-Acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzyl]-phosphonic acid di-tert-butyl ester