221303-31-7

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 221303-30-6 Ac-Phe-Ac₆c-OMe 
• 1161-13-3 N-Cbz-L-Phe 
• 155689-53-5 1-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-cyclohexanecarboxylic acid methyl ester 
• 37993-32-1 1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride 

Downstream Products

• 221303-32-8 1-{2-acetylamino-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionylamino}-cyclohexanecarboxylic acid 
• 264131-80-8 {4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester 

Relevant academic research and scientific papers

Highly potent inhibitors of the Grb2-SH2 domain

Highly potent inhibitors of the Grb2-SH2 domain have been synthesized. They share the common sequence: Ac-Pmp-Ac6c-Asn-NH-(3-indolyl-propyl). Different substituents at the 3-indolyl-propylamine C-terminal group were explored to further improve the activity. This is the first example of inhibitors of SH2 domains with sub-nanomolar affinity reported to date.