(4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

Base Information

Chemical Name:(4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate
CAS No.:1233372-95-6
Molecular Formula:C₆H₈O₇*C₂₁H₃₀FN₃O
Molecular Weight:551.612
Hs Code.:

Synonyms:(4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

Suppliers and Price of (4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

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Chemical Property of (4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

Chemical Property:

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Technology Process of (4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

There total 5 articles about (4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000405-21-9
4-(4-cyclobutylpiperazine-1-carbonyl)benzaldehyde

: 78197-27-0
4-fluoropiperidine

: 1233372-95-6
(4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;
DOI:10.1021/ml5005156

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 1233372-95-6
(4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ml5005156

Reference yield:

: 1-cyclobutyl-piperazine dihydrochloride

: 1233372-95-6
(4-cyclobutylpiperazin-1-yl)(4-((4-fluoropiperidin-1-yl)methyl)phenyl)methanone cytrate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ml5005156