N-(2-methoxyphenyl)-3-phenylprop-2-ynamide

Base Information

Chemical Name:N-(2-methoxyphenyl)-3-phenylprop-2-ynamide
CAS No.:898162-35-1
Molecular Formula:C₁₆H₁₃NO₂
Molecular Weight:251.285
Hs Code.:
DSSTox Substance ID:DTXSID301265781
Nikkaji Number:J2.725.449G

Synonyms:N-(2-methoxyphenyl)-3-phenylprop-2-ynamide;SCHEMBL17372945;DTXSID301265781;HMS1606H05;STK478731;AKOS003359171;N-(2-Methoxyphenyl)benzenepropiolamide;N-(2-Methoxyphenyl)-3-phenyl-2-propynamide;898162-35-1

Suppliers and Price of N-(2-methoxyphenyl)-3-phenylprop-2-ynamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-methoxyphenyl)-3-phenylprop-2-ynamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:251.094628657
Heavy Atom Count:19
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1NC(=O)C#CC2=CC=CC=C2

Technology Process of N-(2-methoxyphenyl)-3-phenylprop-2-ynamide

There total 4 articles about N-(2-methoxyphenyl)-3-phenylprop-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 700-87-8
1-Isocyanato-2-methoxy-benzene

: 536-74-3
phenylacetylene

: 898162-35-1
N-(2-methoxyphenyl)-3-phenyl-2-propynamide

Guidance literature:: phenylacetylene; With trimethylaluminum; triethylamine; In toluene; at 60 ℃; for 6h;

1-Isocyanato-2-methoxy-benzene; In toluene; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1039/d1ob01990b

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 637-44-5
phenylpropyolic acid

: 898162-35-1
N-(2-methoxyphenyl)-3-phenyl-2-propynamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1002/chem.201405672

Reference yield:

: 637-44-5
phenylpropyolic acid

: 898162-35-1
N-(2-methoxyphenyl)-3-phenyl-2-propynamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 3 h / Heating

2: benzene / 1 h / Ambient temperature

With thionyl chloride; In benzene;
DOI:10.1016/0968-0896(96)00053-3