Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI)

Base Information

Chemical Name:Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI)
CAS No.:243665-07-8
Molecular Formula:C₁₀H₁₁F
Molecular Weight:150.196
Hs Code.:
Mol file:243665-07-8.mol

Synonyms:Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI)

Suppliers and Price of Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI)

Chemical Property:

Boiling Point:183.4±19.0 °C(Predicted)
PSA：0.00000
Density:1.060±0.06 g/cm3(Predicted)
LogP:2.94910

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI)

There total 6 articles about Benzene, 1-fluoro-3-[(1R,2R)-2-methylcyclopropyl]-, rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: Methanesulfonic acid (1S,2S)-2-(3-fluoro-phenyl)-cyclopropylmethyl ester

: 243665-07-8
trans-1-methyl-2-(3-fluorophenyl)cyclopropane

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 20 ℃; for 13h;
DOI:10.1139/cjc-77-5-6-1123

Reference yield:

: 1157561-41-5
rac-trans-2-(3-fluorophenyl)-cyclopropanecarboxylic acid

: 243665-07-8
trans-1-methyl-2-(3-fluorophenyl)cyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

2: Et₃N / tetrahydrofuran / 0.5 h / -30 °C

3: 73 percent / LiBEt₃H / tetrahydrofuran / 13 h / 20 °C

With lithium aluminium tetrahydride; lithium triethylborohydride; triethylamine; In tetrahydrofuran; 1: Reduction / 2: Condensation / 3: Reduction;
DOI:10.1139/cjc-77-5-6-1123

Reference yield:

: (trans-2-(3-fluorophenyl)cyclopropyl)methanol

: 243665-07-8
trans-1-methyl-2-(3-fluorophenyl)cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 0.5 h / -30 °C

2: 73 percent / LiBEt₃H / tetrahydrofuran / 13 h / 20 °C

With lithium triethylborohydride; triethylamine; In tetrahydrofuran; 1: Condensation / 2: Reduction;
DOI:10.1139/cjc-77-5-6-1123