N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide

Base Information

• Chemical Name: N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide
• CAS No.: 845786-61-0
• Molecular Formula: C₁₈H₂₅N₅O₂
• Molecular Weight: 343.429
• Mol file: 845786-61-0.mol

Synonyms:N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide

Chemical Property of N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide

There total 4 articles about N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) + (S)-2-[(Benzotriazole-1-carbonyl)-amino]-3-methyl-butyryl chloride (856422-36-1) → N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide (845786-61-0)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; for 24h;

DOI:10.1021/jm040869i

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide (845786-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dioxane / 24 h / 20 °C

2: SOCl₂

3: 0.275 g / Et₃N / toluene / 24 h / 20 °C

With thionyl chloride; triethylamine; In 1,4-dioxane; toluene;

DOI:10.1021/jm040869i

Reference yield:

1-benzotriazolecarboxylic acid chloride (65095-13-8) → N-(1-benzotriazolecarbonyl)-L-valine cyclohexylamide (845786-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dioxane / 24 h / 20 °C

2: SOCl₂

3: 0.275 g / Et₃N / toluene / 24 h / 20 °C

With thionyl chloride; triethylamine; In 1,4-dioxane; toluene;

DOI:10.1021/jm040869i

upstream raw materials:

cyclohexylamine

(S)-2-[(Benzotriazole-1-carbonyl)-amino]-3-methyl-butyryl chloride

L-valine

1-benzotriazolecarboxylic acid chloride

Refernces