(Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

Base Information

Chemical Name:(Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile
CAS No.:1401545-59-2
Molecular Formula:C₃₅H₂₄N₂OS
Molecular Weight:520.654
Hs Code.:

Synonyms:(Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

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Chemical Property of (Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

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Technology Process of (Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

There total 5 articles about (Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1401545-49-0
(Z)-2-(4-bromophenyl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)thio-phen-3-yl)-phenyl)acrylonitrile

: 5720-07-0
4-methoxyphenylboronic acid

: 1401545-59-2
(Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 85 ℃; Inert atmosphere;
DOI:10.1016/j.dyepig.2012.05.019

Reference yield:

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 1401545-59-2
(Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / ethanol / 4 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 8 h / 85 °C / Inert atmosphere

3: sodium methylate / ethanol / 60 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 2: Suzuki coupling / 4: Suzuki coupling;
DOI:10.1016/j.dyepig.2012.05.019

Reference yield:

: 1353756-31-6
C₁₃H₈BrNS

: 1401545-59-2
(Z)-3-(4-(4-((Z)-2-cyano-2-(4'-methoxy-[1,1'-biphenyl]-4-yl)vinyl)phenyl)-thiophen-2-yl)-2-phenylacrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 8 h / 85 °C / Inert atmosphere

2: sodium methylate / ethanol / 60 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 1: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1016/j.dyepig.2012.05.019