4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

Base Information

Chemical Name:4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine
CAS No.:1027427-91-3
Molecular Formula:C₁₉H₂₃F₃N₄O
Molecular Weight:380.413
Hs Code.:

Synonyms:4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

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Chemical Property of 4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

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Technology Process of 4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

There total 7 articles about 4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856400-15-2
2-nitro-4-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethoxy)aniline

: 1027427-91-3
4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

Guidance literature:: With Ra-Ni; hydrazine hydrate; In ethanol; 1,2-dichloro-ethane; at 50 ℃; for 1h;
DOI:10.1016/j.ejmech.2004.10.006

Reference yield:

: 681259-29-0
4-(2-chloroethoxy)-2-nitroaniline

: 1027427-91-3
4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / K₂CO₃; KI / dimethylformamide / 24 h / 80 °C

2: Ra-Ni; hydrazine hydrate / ethanol; 1,2-dichloro-ethane / 1 h / 50 °C

With Ra-Ni; potassium carbonate; hydrazine hydrate; potassium iodide; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.10.006

Reference yield:

: 672961-06-7
N-[4-(2-chloroethoxy)-2-nitrophenyl]acetamide

: 1027427-91-3
4-[2-(4-(3-trifluoromethylphenyl)piperazin-1-yl)-ethoxy]-benzene-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / aq. HCl / 4 h / Heating

2: 72 percent / K₂CO₃; KI / dimethylformamide / 24 h / 80 °C

3: Ra-Ni; hydrazine hydrate / ethanol; 1,2-dichloro-ethane / 1 h / 50 °C

With hydrogenchloride; Ra-Ni; potassium carbonate; hydrazine hydrate; potassium iodide; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2004.10.006