N³-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil

Base Information

• Chemical Name: N³-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil
• CAS No.: 245074-31-1
• Molecular Formula: C₄₄H₃₈N₂O₁₀
• Molecular Weight: 754.793

Synonyms:N³-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil

Chemical Property of N³-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil

Chemical Property:

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Technology Process of N³-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil

There total 3 articles about N³-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N3-benzoyl-1-(2'-O-benzoyl-β-D-ribopyranosyl)uracil (245074-24-2) → N3-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil (245074-31-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/hlca.200390349

Reference yield:

benzoyl chloride (98-88-4) → N3-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil (245074-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DMAP / pyridine / 16 h / 20 °C

1.2: 70 percent / CF₃COOH / methanol; tetrahydrofuran / 1 h / 20 °C

2.1: 86 percent / 4A MS; EtN(i-Pr)2 / CH₂Cl₂ / 1 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;

DOI:10.1002/hlca.200390349

Reference yield:

1-{3',4'-O-[(4-methoxyphenyl)methylidene]-β-D-ribopyranosyl}uracil → N3-benzoyl-1-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil (245074-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DMAP / pyridine / 16 h / 20 °C

1.2: 70 percent / CF₃COOH / methanol; tetrahydrofuran / 1 h / 20 °C

2.1: 86 percent / 4A MS; EtN(i-Pr)2 / CH₂Cl₂ / 1 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;

DOI:10.1002/hlca.200390349

upstream raw materials:

4,4'-dimethoxytrityl chloride

N³-benzoyl-1-(2'-O-benzoyl-β-D-ribopyranosyl)uracil

benzoyl chloride

Downstream raw materials:

1-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}uracil

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