Pyridine-15N

Base Information

• Chemical Name: Pyridine-15N
• CAS No.: 34322-45-7
• Molecular Formula: C5H5 N
• Molecular Weight: 80.11
• European Community (EC) Number: 689-482-7
• DSSTox Substance ID: DTXSID10480016
• Nikkaji Number: J704.764I
• Wikidata: Q82314479
• Mol file: 34322-45-7.mol

Synonyms:Pyridine-15N;34322-45-7;(115N)pyridine;Pyridine(15N);DTXSID10480016;Pyridine-15N, 98 atom % 15N;J-019554

Chemical Property of Pyridine-15N

Chemical Property:

• Vapor Pressure: 10 mm Hg ( 13.2 °C)
• Melting Point: −42 °C(lit.)
• Boiling Point: 115 °C(lit.)
• Flash Point: 68 °F
• PSA: 12.89000
• Density: 0.990 g/mL at 25 °C
• LogP: 1.08160
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 80.039234058
• Heavy Atom Count: 6
• Complexity: 30.9

Purity/Quality:

99%+ ^*data from raw suppliers

Pyridine-15N ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 11-20/21/22
• Safety Statements: 16-23-26-36-28

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=NC=C1
• Isomeric SMILES: C1=CC=[15N]C=C1
• Uses: Pyridine-15N, is the labeled analogue of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.

Technology Process of Pyridine-15N

There total 4 articles about Pyridine-15N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-ethoxy-2,3-dihydro-4H-pyran (103-75-3) → pyridine (34322-45-7)

Guidance literature:

With sulfuric acid; ¹⁵N-ammoniumchloride; methylene blue; In ethanol; for 2h; Reflux;

DOI:10.1002/chem.201900430

Reference yield:

pyridine (110-86-1) → pyridine (34322-45-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 48 h / 20 °C / Inert atmosphere

2.1: ammonium-¹⁵N hydrochloride; sodium methylate / methanol / 48 h / 0 °C / Inert atmosphere

2.2: pH Ca_. 2

3.1: sodium hydroxide / Heating

With ammonium-¹⁵N hydrochloride; sodium methylate; sodium hydroxide; In methanol;

DOI:10.1002/jlcr.3699

Reference yield:

15N-pyridine hydrochloride → pyridine (34322-45-7)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1002/jlcr.3699

upstream raw materials:

2-ethoxy-2,3-dihydro-4H-pyran

pyridine

Downstream raw materials:

2-Amino<15N>pyridne