1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol

Base Information

• Chemical Name: 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol
• CAS No.: 502610-10-8
• Molecular Formula: C₂₅H₂₇NO₅S
• Molecular Weight: 453.559
• Mol file: 502610-10-8.mol

Synonyms:1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol

Chemical Property of 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol

There total 3 articles about 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methanesulfonyl-phenol (14763-60-1) → 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol (502610-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol

2: lithium diisopropylamide

With sodium hydroxide; lithium diisopropyl amide; In ethanol; 2: Julia coupling;

DOI:10.1016/j.bmcl.2004.03.048

Reference yield:

4-chloromethyl-2-methylquinoline hydrochloride salt → 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol (502610-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol

2: lithium diisopropylamide

With sodium hydroxide; lithium diisopropyl amide; In ethanol; 2: Julia coupling;

DOI:10.1016/j.bmcl.2004.03.048

Reference yield:

4-tetrahydropyranylidene acetaldehyde + 4-(2-methylquinolin-4-ylmethoxy)phenylsulphonylmethane (441297-69-4) → 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol (502610-10-8)

Guidance literature:

4-(2-methylquinolin-4-ylmethoxy)phenylsulphonylmethane; With lithium diisopropyl amide;

4-tetrahydropyranylidene acetaldehyde;

DOI:10.1016/j.bmcl.2004.03.048

upstream raw materials:

4-(2-methylquinolin-4-ylmethoxy)phenylsulphonylmethane

4-methanesulfonyl-phenol

Downstream raw materials:

2-methyl-4-{4-[3-(tetrahydropyran-4-ylidene)prop-1-ene-1-sulfonyl]phenoxymethyl}quinoline