441297-69-4

Upstream product

• 14763-60-1 4-methanesulfonyl-phenol 
• 675185-53-2 4-(2-methylquinolin-4-ylmethoxy)phenylthiomethane 

Downstream Products

• 502610-10-8 1-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-3-(tetrahydropyran-4-ylidene)propan-2-ol 
• 502610-19-7 N-{1-(1-Isobutylpiperidin-4-ylidenemethyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethyl}hydroxylamine 
• 502609-89-4 4-[2-Hydroxyamino-3-{4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl}propyliden]cyclohexanone 
• 502609-87-2 4-[2-Hydroxyamino-3-{4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl}propyl]cyclohexanone 
• 502610-12-0 N-{2-[4-(2-Methylquinolin-4-ylmethoxy)benzenesulfonyl]-1-(tetrahydrothiopyran-4-ylidenemethyl)ethyl}hydroxylamine 
• 502607-70-7 N-Hydroxy-N-{2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]-1-(tetrahydropyran-4-ylidenemethyl)ethyl}formamide 
• 502609-81-6 1-(4-methylenecyclohexyl)-2-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonyl]ethanol 

Relevant academic research and scientific papers

SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS

Sulphonamide derivatives that are useful in the inhibition of metalloproteinases and in particular in the inhibition of TNF-α Converting Enzyme (TACE).

REVERSE HYDROXAMIC ACID DERIVATIVES

Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Ar1 is an arylene or the like; Ar2 is an optionally substituted aryl, a heteroaryl or the

Reverse hydroxamate-based selective TACE inhibitors

Reverse hydroxamate-based selective TACE inhibitors are described. They have potent TACE inhibitory activities and excellent selectivities against MMP-1, 2, 3, 8, 9, 13, 14, and 17. One representative compound, 18 has demonstrated an excellent oral inhibitory activity of the lipopolysaccharide (LPS)-stimulated TNF-α production in rats.