C₁₉H₁₆F₃N₅O₂

Base Information

Chemical Name:C₁₉H₁₆F₃N₅O₂
CAS No.:787640-42-0
Molecular Formula:C₁₉H₁₆F₃N₅O₂
Molecular Weight:403.364
Hs Code.:

C<sub>19</sub>H<sub>16</sub>F<sub>3</sub>N<sub>5</sub>O<sub>2</sub>

Synonyms:C₁₉H₁₆F₃N₅O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₉H₁₆F₃N₅O₂

Chemical Property:

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Technology Process of C₁₉H₁₆F₃N₅O₂

There total 8 articles about C₁₉H₁₆F₃N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 787640-41-9
benzyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 407-25-0
trifluoroacetic anhydride

: 787640-42-0
C₁₉H₁₆F₃N₅O₂

Guidance literature:: benzyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate; trifluoroacetic anhydride; With pyridine; In dichloromethane; at 20 ℃; for 5h;

With triphenylphosphine; In tetrachloromethane; for 15h; Heating / reflux;

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 787640-42-0
C₁₉H₁₆F₃N₅O₂

Guidance literature:: Multi-step reaction with 8 steps

1: sulfuric acid; potassium nitrate / 18 h / 5 - 20 °C

2: pyridine / 18 h / 0 - 20 °C

3: hydrogen / platinum(IV) oxide / ethanol / 2585.81 Torr

4: potassium carbonate / ethanol; water / 1.5 h / Heating / reflux

5: triethylamine / tetrahydrofuran / 4 h / 20 °C

6: pyridine / dichloromethane / 5 h / 0 - 20 °C

7: triphenylphosphine / tetrachloromethane / 15 h / Heating / reflux

8: sodium azide / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C / Heating / reflux

With pyridine; sodium azide; sulfuric acid; hydrogen; potassium carbonate; potassium nitrate; triethylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water;

Reference yield:

: 42923-79-5
7-nitro-1,2,3,4-tetrahydroisoquinoline

: 787640-42-0
C₁₉H₁₆F₃N₅O₂

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 18 h / 0 - 20 °C

2: hydrogen / platinum(IV) oxide / ethanol / 2585.81 Torr

3: potassium carbonate / ethanol; water / 1.5 h / Heating / reflux

4: triethylamine / tetrahydrofuran / 4 h / 20 °C

5: pyridine / dichloromethane / 5 h / 0 - 20 °C

6: triphenylphosphine / tetrachloromethane / 15 h / Heating / reflux

7: sodium azide / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C / Heating / reflux

With pyridine; sodium azide; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water;