(1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Base Information

Chemical Name:(1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
CAS No.:1453070-34-2
Molecular Formula:C₃₂H₃₅ClF₃N₃O₂
Molecular Weight:586.097
Hs Code.:

Synonyms:(1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Chemical Property of (1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

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Technology Process of (1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

There total 17 articles about (1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1453069-67-4
(1S,8aS)-7,7-diallyl-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-6(7H)-one

: 1453070-33-1
(R)-1-(3-chloro-5-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine

: 1453070-34-2
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: bis(trichloromethyl) carbonate; (1S,8aS)-7,7-diallyl-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-6(7H)-one; With dmap; triethylamine; In ethyl acetate; at 0 ℃; for 1.5h;

(R)-1-(3-chloro-5-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine; With triethylamine; In ethyl acetate; at 50 ℃; for 48h;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1453070-34-2
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

5.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

6.2: 3 h / -60 - 20 °C

7.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 5 h / 80 °C / Inert atmosphere

8.1: copper dichloride; water / methanol / 10 h / 80 °C

9.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

9.2: 48 h / 50 °C

With titanium(IV) isopropylate; dmap; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; water; diisobutylaluminium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; copper dichloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453070-34-2
(1S,8aS)-7,7-diallyl-N-((R)-1-(3-chloro-5-(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6 h / 0 - 20 °C

3.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

4.2: 3 h / -60 - 20 °C

5.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 5 h / 80 °C / Inert atmosphere

6.1: copper dichloride; water / methanol / 10 h / 80 °C

7.1: triethylamine; dmap / ethyl acetate / 1.5 h / 0 °C

7.2: 48 h / 50 °C

With titanium(IV) isopropylate; dmap; bis-triphenylphosphine-palladium(II) chloride; water; diisobutylaluminium hydride; potassium carbonate; triethylamine; copper dichloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;