5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

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Chemical Name:5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine
CAS No.:1256908-00-5
Molecular Formula:C₂₃H₁₉Cl₂N₅
Molecular Weight:436.343
Hs Code.:

Synonyms:5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

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Chemical Property of 5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

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Technology Process of 5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

There total 2 articles about 5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 934996-36-8
[benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde

: 106-47-8
4-chloro-aniline

: 1256908-00-5
5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo101798p

Reference yield:

: 1027921-41-0
6-[N-benzyl(2-hydroxyethyl)amino]-4-chloro-5-pyrrol-1-yl-pyrimidine

: 1256908-00-5
5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0.58 h / 20 °C

2: dichloromethane / 1 h / 20 °C

With sulfur trioxide pyridine complex; triethylamine; In dichloromethane; dimethyl sulfoxide; 1: Parikh-Doering oxidation;
DOI:10.1021/jo101798p

Reference yield: 83.0%

: 1256908-00-5
5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine

: N-benzyl-1-[1-chloro-5-(4-chlorophenyl)-5,6-dihydropyrrolo[1,2-f]pteridin-6-yl]methanamine

Guidance literature:: 5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine; With 4-methoxy-aniline; trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 36h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;
DOI:10.1021/jo101798p