[benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde

Base Information

• Chemical Name: [benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde
• CAS No.: 934996-36-8
• Molecular Formula: C₁₇H₁₅ClN₄O
• Molecular Weight: 326.785
• Mol file: 934996-36-8.mol

Synonyms:[benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde

Chemical Property of [benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of [benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde

There total 2 articles about [benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-[N-benzyl(2-hydroxyethyl)amino]-4-chloro-5-pyrrol-1-yl-pyrimidine (1027921-41-0) → [benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde (934996-36-8)

Guidance literature:

With pyridine-SO₃ complex; triethylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 0.583333h;

DOI:10.1021/ol0629364

Reference yield:

4,6-dichloro-5-(1H-pyrrol-1-yl)pyrimidine (934996-35-7) → [benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde (934996-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / triethylamine / butan-1-ol / 3.5 h / Heating

2: triethylamine; SO₃*pyridine / CH₂Cl₂; dimethylsulfoxide / 0.58 h / 20 °C

With pyridine-SO₃ complex; triethylamine; In dichloromethane; dimethyl sulfoxide; butan-1-ol; 2: Parikh-Doering oxidation;

DOI:10.1021/ol0629364

Reference yield: 59.0%

[benzyl-(6-chloro-5-pyrrol-1-yl-pyrimidin-4-yl)-amino]-acetaldehyde (934996-36-8) + 4-chloro-aniline (106-47-8) → 5-benzyl-1-chloro-N-(4-chlorophenyl)-6,7-dihydro-5H-pyrimido[4,5-b]pyrrolo[1,2-d][1,4]diazepin-7-amine (1256908-00-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo101798p

upstream raw materials:

6-[N-benzyl(2-hydroxyethyl)amino]-4-chloro-5-pyrrol-1-yl-pyrimidine

4,6-dichloro-5-(1H-pyrrol-1-yl)pyrimidine