(S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Base Information

Chemical Name:(S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione
CAS No.:191474-58-5
Molecular Formula:C₂₅H₂₄F₃N₃O₅
Molecular Weight:503.478
Hs Code.:

Synonyms:(S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

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Chemical Property of (S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

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Technology Process of (S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

There total 6 articles about (S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 191474-57-4
N-{(S)-1-(2,4-Dimethoxy-benzylcarbamoyl)-2-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-2-oxo-propionamide

: 191474-58-5
(S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Guidance literature:: With trifluoroacetic acid; In toluene; Heating;
DOI:10.1055/s-1997-6137

Reference yield:

: 191474-53-0
[(S)-1-(2,4-Dimethoxy-benzylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester

: 191474-58-5
(S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / BH₃, TFA / tetrahydrofuran

2: 97 percent / Et₃N

3: 100 percent / H₂ / Pd/C

4: 63 percent

5: 89 percent / TFA / toluene / Heating

With borane; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; toluene;
DOI:10.1055/s-1997-6137

Reference yield:

: 191474-54-1
[(S)-2-(2,3-Dihydro-1H-indol-3-yl)-1-(2,4-dimethoxy-benzylcarbamoyl)-ethyl]-carbamic acid benzyl ester

: 191474-58-5
(S)-1-(2,4-Dimethoxy-benzyl)-6-methylene-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / Et₃N

2: 100 percent / H₂ / Pd/C

3: 63 percent

4: 89 percent / TFA / toluene / Heating

With hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In toluene;
DOI:10.1055/s-1997-6137