2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

Base Information

Chemical Name:2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol
CAS No.:1608144-50-8
Molecular Formula:C₂₂H₂₂ClN₃O₅
Molecular Weight:443.887
Hs Code.:

Synonyms:2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

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Chemical Property of 2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

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Technology Process of 2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

There total 10 articles about 2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1608147-60-9
tert-butyl N-[5-(5-{5-[3-chloro-4-isopropoxyphenyl]-1,2,4-oxadiazol-3-yl}-1-benzofuran-2-yl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamate

: 1608144-50-8
2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

Guidance literature:: With methanesulfonic acid; In ethanol; for 0.5h; Reflux;

Reference yield:

: 1220973-38-5
N-hydroxy-3-iodo-4-isopropoxybenzimidamide

: 1608144-50-8
2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

3: boron trichloride / dichloromethane / 20 °C

4: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

6: methanesulfonic acid / ethanol / 0.5 h / Reflux

With pyridine; copper(I) oxide; methanesulfonic acid; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1608147-52-9
N-(3-chloro-4-hydroxybenzoyloxy)-3-iodo-4-isopropoxybenzimidamide

: 1608144-50-8
2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

2: boron trichloride / dichloromethane / 20 °C

3: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

5: methanesulfonic acid / ethanol / 0.5 h / Reflux

With pyridine; copper(I) oxide; methanesulfonic acid; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;