2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

Base Information

Chemical Name:2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid
CAS No.:1608144-51-9
Molecular Formula:CH₄O₃S*C₂₂H₂₂ClN₃O₅
Molecular Weight:539.994
Hs Code.:

Synonyms:2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

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Chemical Property of 2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

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Technology Process of 2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

There total 11 articles about 2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1608144-50-8
2-amino-2-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol

: 1608144-51-9
2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

Guidance literature:: In methanol; at 20 ℃;

Reference yield:

: 59595-94-7
3?chloro?4-hydroxybenzoyl chloride

: 1608144-51-9
2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

3: boron trichloride / dichloromethane / 20 °C

4: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

6: methanesulfonic acid / ethanol / 0.5 h / Reflux

7: methanol / 20 °C

With pyridine; copper(I) oxide; methanesulfonic acid; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1608144-51-9
2-amino-2-(5-(5-(4-isopropoxy-3-chlorophenyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol methanesulfonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -5 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / dimethyl sulfoxide; tetrahydrofuran / 1 h / 110 °C / Inert atmosphere

4: boron trichloride / dichloromethane / 20 °C

5: copper(I) oxide; pyridine / 1 h / 110 °C / Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

7: methanesulfonic acid / ethanol / 0.5 h / Reflux

8: methanol / 20 °C

With pyridine; copper(I) oxide; oxalyl dichloride; methanesulfonic acid; tetrabutyl ammonium fluoride; boron trichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;