(2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

Base Information

Chemical Name:(2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane
CAS No.:103233-25-6
Molecular Formula:C₂₅H₂₆O₂
Molecular Weight:358.48
Hs Code.:

Synonyms:(2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

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Chemical Property of (2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

Chemical Property:

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Technology Process of (2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

There total 11 articles about (2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128329-09-9
(2R,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-5-trityloxy-pentan-2-ol

: 103233-25-6
(2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

Guidance literature:: With tetrabutyl ammonium fluoride; methanesulfonyl chloride; Yield given. Multistep reaction; 1.) pyr., room temperature, 2 h, 2.) THF, room temperature, 1 h;
DOI:10.1016/S0040-4039(01)80904-7

Reference yield:

: 128329-08-8
(2R,4R)-5-(tert-butyldiphenylsilyloxy)-2-methylpentane-1,4-diol

: 103233-25-6
(2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine; various solvent(s) / 18 h / Ambient temperature

2: 1.) CH₃SO₂Cl, 2.) Bu₄N(+)F(-) / 1.) pyr., room temperature, 2 h, 2.) THF, room temperature, 1 h

With tetrabutyl ammonium fluoride; methanesulfonyl chloride; In pyridine;
DOI:10.1016/S0040-4039(01)80904-7

Reference yield:

: 128440-18-6
(3R,5R)-5-(tert-butyldiphenylsilyloxymethyl)-3-methyl-dihydrofuran-2(3H)-one

: 103233-25-6
(2R,4R)-1,2-epoxy-4-methyl-5-(triphenylmethoxy)pentane

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / BH₃*Me₂S / tetrahydrofuran / 18 h

2: 14.38 g / NEt₃, DMAP / CH₂Cl₂ / 6 h

3: NEt₃ / CH₂Cl₂ / 1 h / 0 °C

4: 1.) n-Bu₄NF, 2.) 30percent sodium methoxide / 1.) THF, 18 h, 2.) methanol, 0.5 h

With dmap; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; sodium methylate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00169a041