4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

Base Information

Chemical Name:4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine
CAS No.:1026724-20-8
Molecular Formula:C₂₁H₃₄N₂O₂Si₂
Molecular Weight:402.684
Hs Code.:

Synonyms:4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

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Chemical Property of 4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

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Technology Process of 4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

There total 1 articles about 4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10416-59-8
N,O-bis-(trimethylsilyl)-acetamide

: 171048-65-0
6-(3,5-dimethylbenzyl)-5-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

: 1026724-20-8
4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

Guidance literature:: In chloroform; for 0.166667h;
DOI:10.1021/jm040845b

Reference yield:

: 1026724-20-8
4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

: 847995-43-1
6-(3,5-dimethyl-benzyl)-5-ethyl-1-(4-hydroxy-benzyloxymethyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuryl chloride / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 0.117 g / CsI / CHCl₃ / 20 °C

2.1: 81 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 20 °C

With sulfuryl dichloride; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm040845b

Reference yield:

: 1026724-20-8
4-(3,5-dimethyl-benzyl)-5-ethyl-2,6-bis-trimethylsilanyloxy-pyrimidine

: 2,2-dimethyl-thiopropionic acid 2-{{4-[6-(3,5-dimethyl-benzyl)-5-ethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxymethyl]-phenoxy}-[5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethoxy]-phosphoryloxy}-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuryl chloride / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 0.117 g / CsI / CHCl₃ / 20 °C

2.1: 81 percent / H₂ / Pd/C / CH₂Cl₂; methanol / 20 °C

3.1: 1H-tetrazole; 3A molecular sieves / acetonitrile / 2.5 h / 20 °C

3.2: 60 percent / tert-butylhydroperoxide / acetonitrile; decane / 1 h

With 1H-tetrazole; sulfuryl dichloride; 3 A molecular sieve; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm040845b