2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid

Base Information

Chemical Name:2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid
CAS No.:73790-12-2
Molecular Formula:C₁₁H₅F₉O₂
Molecular Weight:340.145
Hs Code.:
DSSTox Substance ID:DTXSID801136070

Synonyms:73790-12-2;2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid;DTXSID801136070;2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)aceticacid;alpha,alpha-Difluoro-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]benzeneacetic acid

Suppliers and Price of 2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:3
Exact Mass:340.01458286
Heavy Atom Count:22
Complexity:404

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(C(=O)O)(F)F)C(C(F)(F)F)(C(F)(F)F)F

Technology Process of 2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid

There total 3 articles about 2,2-Difluoro-2-(4-(perfluoropropan-2-yl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 73789-97-6
ethyl α,α-difluoro-4-(perfluoroisopropyl)benzeneacetate

: 73790-12-2
α,α-difluoro-4-(perfluoroisopropyl)benzeneacetic acid

Guidance literature:: With hydrogen iodide; In acetic acid; Heating;
DOI:10.1021/jo01302a025

Reference yield:

: 2396-23-8
1-bromo-4-(perfluoropropan-2-yl)benzene

: 73790-12-2
α,α-difluoro-4-(perfluoroisopropyl)benzeneacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1)butyllithium / in diethyl ether, hexane, 1a) -60 deg C, b) RT, 2) -60 deg C

2: 75 percent / (diethylamino)sulfur trifluoride

3: 97 percent / 58percent hydriodic acid / acetic acid / Heating

With n-butyllithium; diethylamino-sulfur trifluoride; hydrogen iodide; In acetic acid;
DOI:10.1021/jo01302a025

Reference yield:

: 73790-07-5
ethyl α-oxo-4-(perfluoroisopropyl)benzeneacetate

: 73790-12-2
α,α-difluoro-4-(perfluoroisopropyl)benzeneacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / (diethylamino)sulfur trifluoride

2: 97 percent / 58percent hydriodic acid / acetic acid / Heating

With diethylamino-sulfur trifluoride; hydrogen iodide; In acetic acid;
DOI:10.1021/jo01302a025