(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

Base Information

Chemical Name:(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid
CAS No.:134405-60-0
Molecular Formula:C₂₇H₃₁ClN₂O₅
Molecular Weight:499.007
Hs Code.:

Synonyms:(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

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Chemical Property of (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

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Technology Process of (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

There total 10 articles about (E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026196-89-3
(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid methyl ester

: 134405-60-0
(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 25 ℃; for 2h;
DOI:10.1021/jm00099a013

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 134405-60-0
(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

7: DBU / toluene / 1 h / 100 °C

8: 10percent aq. NaOH / ethanol / 2 h / 25 °C

With dmap; manganese(IV) oxide; sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00099a013

Reference yield:

: 68283-19-2
2-n-butyl-4-(hydroxymethyl)imidazole

: 134405-60-0
(E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(3,4,5-trimethoxy-benzyl)-acrylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 83 percent / 19 h / Ambient temperature

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

7: DBU / toluene / 1 h / 100 °C

8: 10percent aq. NaOH / ethanol / 2 h / 25 °C

With dmap; manganese(IV) oxide; sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium diisopropyl amide; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jm00099a013