tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

Base Information

Chemical Name:tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane
CAS No.:1415934-60-9
Molecular Formula:C₂₉H₃₆O₄Si
Molecular Weight:476.688
Hs Code.:

Synonyms:tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

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Chemical Property of tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

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Technology Process of tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

There total 3 articles about tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 128329-22-6
(2R,3S)-<(tert-butyldiphenylsilyl)oxy>-2-methyl-1,3-butanediol

: 1415934-60-9
tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

Guidance literature:: With 10-camphorsufonic acid; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol3030692

Reference yield:

: 1415934-59-6
(2S,3S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-4-(tert-butyldiphenylsilyloxy)-3-hydroxy-2-methylbutan-1-one

: 1415934-60-9
tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C / Inert atmosphere

2: 10-camphorsufonic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; 10-camphorsufonic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol3030692

Reference yield:

: 115869-43-7
(tert-butyldiphenylsilanyloxy)acetaldehyde

: 1415934-60-9
tert-butyl(((4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methoxy)diphenylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium tetrachloride / dichloromethane / 0.08 h / 0 °C / Inert atmosphere

1.2: 0.92 h / 0 °C / Inert atmosphere

1.3: 3 h / -78 - 0 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C / Inert atmosphere

3.1: 10-camphorsufonic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; 10-camphorsufonic acid; titanium tetrachloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol3030692