ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

Base Information

Chemical Name:ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate
CAS No.:540745-56-0
Molecular Formula:C₂₃H₂₈O₄
Molecular Weight:368.473
Hs Code.:

Synonyms:ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

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Chemical Property of ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

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Technology Process of ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

There total 4 articles about ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-39-0
benzyl bromide

: 540745-54-8
ethyl [1-hydroxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

: 540745-56-0
ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(03)00181-9

Reference yield:

: 540745-50-4
ethyl 2-(2-bromomethylcyclopent-2-enon-3-yl)propionate

: 540745-56-0
ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / 2M K₃PO₄ / Pd(PPh₃)4 / tetrahydrofuran / 2 h / Heating

2: 88 percent / CeCl₃; NaBH₄ / methanol / 0.5 h

3: 92 percent / NaH / dimethylformamide / 2 h / 20 °C

With sodium tetrahydroborate; potassium phosphate; cerium(III) chloride; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/S0040-4020(03)00181-9

Reference yield:

: 540745-48-0
ethyl 2-(2-hydroxymethylcyclopent-2-enon-3-yl)propionate

: 540745-56-0
ethyl [1-benzyloxy-2-(4-methylfuran-3-yl)methylcyclopent-2-en-3-yl]propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / PBr₃ / diethyl ether / 0.5 h / 0 °C

2: 55 percent / 2M K₃PO₄ / Pd(PPh₃)4 / tetrahydrofuran / 2 h / Heating

3: 88 percent / CeCl₃; NaBH₄ / methanol / 0.5 h

4: 92 percent / NaH / dimethylformamide / 2 h / 20 °C

With sodium tetrahydroborate; potassium phosphate; cerium(III) chloride; phosphorus tribromide; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/S0040-4020(03)00181-9