(Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone

Base Information

• Chemical Name: (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone
• CAS No.: 1634722-76-1
• Molecular Formula: C₂₅H₁₆ClN₃O₄S₃
• Molecular Weight: 554.071

Synonyms:(Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone

Chemical Property of (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone

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Technology Process of (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone

There total 3 articles about (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-oxo-N-(4-chlorophenyl)propanehydrazonoyl chloride (18247-78-4,1338563-31-7) + (Z)-1-(benzothiazol-2-yl)-3-mercapto-3-(phenylamino)-2-(phenylsulfonyl)prop-2-en-1-one (1634722-92-1) → (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone (1634722-76-1)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 12h;

DOI:10.3987/COM-14-13020

Reference yield:

1-(benzothiazol-2-yl)-2-phenylsulfonyl-1-ethanone (1591907-98-0) → (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone (1634722-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

1.3: Cooling with ice

2.1: triethylamine / ethanol / 12 h / 20 °C

With triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.3987/COM-14-13020

Reference yield:

phenyl isothiocyanate (103-72-0) → (Z)-2-(5-acetyl-3-(4-chlorophenyl)-1,3,4-thiadiazol-2(3H)-ylidene)-1-(benzothiazol-2-yl)-2-(phenylsulfonyl)ethanone (1634722-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

1.3: Cooling with ice

2.1: triethylamine / ethanol / 12 h / 20 °C

With triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.3987/COM-14-13020

upstream raw materials:

1-(benzothiazol-2-yl)-2-phenylsulfonyl-1-ethanone

2-oxo-N-(4-chlorophenyl)propanehydrazonoyl chloride

(Z)-1-(benzothiazol-2-yl)-3-mercapto-3-(phenylamino)-2-(phenylsulfonyl)prop-2-en-1-one

phenyl isothiocyanate

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