4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

Base Information

Chemical Name:4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile
CAS No.:1541987-92-1
Molecular Formula:C₂₂H₁₅N₅O₂
Molecular Weight:381.393
Hs Code.:

Synonyms:4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

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Chemical Property of 4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

Chemical Property:

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Technology Process of 4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

There total 9 articles about 4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1541987-89-6
N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

: 1541987-92-1
4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

Guidance literature:: With acetic acid; for 12h; Reflux;
DOI:10.1021/jo402599s

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1541987-92-1
4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C

2: iron; ammonium chloride / isopropyl alcohol / 4 h / Reflux

3: triethylamine / dichloromethane / 20 °C

4: acetic acid / 12 h / Reflux

With iron; sodium hydride; ammonium chloride; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jo402599s

Reference yield:

: 1541987-83-0
4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile

: 1541987-92-1
4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / isopropyl alcohol / 4 h / Reflux

2: triethylamine / dichloromethane / 20 °C

3: acetic acid / 12 h / Reflux

With iron; ammonium chloride; acetic acid; triethylamine; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jo402599s