N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

Base Information

Chemical Name:N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide
CAS No.:1541987-89-6
Molecular Formula:C₂₂H₁₇N₅O₃
Molecular Weight:399.409
Hs Code.:

Synonyms:N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

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Technology Process of N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

There total 7 articles about N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1541987-85-2
4-[[(5,6-diaminopyridin-2-yl)oxy]methyl]benzonitrile

: 55368-68-8
2-(4-cyanophenoxy)acetyl chloride

: 1541987-89-6
N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo402599s

Reference yield:

: 874-89-5
4-Cyanobenzyl alcohol

: 1541987-89-6
N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C

2: iron; ammonium chloride / isopropyl alcohol / 4 h / Reflux

3: triethylamine / dichloromethane / 20 °C

With iron; sodium hydride; ammonium chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1021/jo402599s

Reference yield:

: 1541987-83-0
4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile

: 1541987-89-6
N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / isopropyl alcohol / 4 h / Reflux

2: triethylamine / dichloromethane / 20 °C

With iron; ammonium chloride; triethylamine; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jo402599s