{4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

Base Information

Chemical Name:{4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine
CAS No.:1015445-54-1
Molecular Formula:C₂₄H₂₃FN₄S
Molecular Weight:418.538
Hs Code.:

Synonyms:{4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

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Chemical Property of {4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

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Technology Process of {4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

There total 12 articles about {4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 2627-86-3
(S)-1-phenyl-ethylamine

: 549505-66-0
2-fluoro-4-[4-(4-fluorophenyl)-1-methyl-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine

: 1015445-54-1
{4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

Guidance literature:: In ethyl acetate; at 165 ℃; for 17h;
DOI:10.1021/jm701529q

Reference yield: 39.0%

: 2627-86-3
(S)-1-phenyl-ethylamine

: 2-chloro-4-(4-(4-fluorophenyl)-1-methyl-2-(methylthio)-1H-imidazol-5-yl)pyridine

: 1015445-54-1
{4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

Guidance literature:: at 180 ℃; Sealed tube;
DOI:10.3390/molecules23010221

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 1015445-54-1
{4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: -30 - -25 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / water; methanol / 48 h / 20 °C

3.1: pyridine / 50 h / 20 °C / Inert atmosphere

4.1: potassium ethoxide / ethanol; diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h

5.1: triethylamine / 50 °C / Sealed tube

6.1: acetic acid / 80 °C

7.1: sodium t-butanolate / methanol / 0 - 50 °C / Sealed tube

8.1: 180 °C / Sealed tube

With pyridine; hydroxylamine hydrochloride; potassium ethoxide; magnesium; acetic acid; triethylamine; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; 1.2: |Grignard Reaction / 4.1: |Neber Rearrangement;
DOI:10.3390/molecules23010221