549505-66-0

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 549505-59-1 2-fluoro-4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridine 
• 74-88-4 methyl iodide 
• 1015445-65-4 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1-methyl-1,3-dihydro-2H-imidazole-2-thione 
• 1015445-80-3 5-bromo-4-(4-fluorophenyl)-1-methyl-2-(methylsulfanyl)-1H-imidazole 
• 401815-98-3 2-fluoropyridin-4-ylboronic acid 
• 452056-98-3 4-[4-(4-fluorophenyl)-1-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamine 

Downstream Products

• 908382-46-7 2-Fluoro-4-[5-(4-fluorophenyl)-3-methyl-2-methanesulfinyl-3H-imidazol-4-yl]-pyridine 
• 908382-34-3 CBS-3435 
• 1015445-54-1 {4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((S)-1-phenylethyl)amine 
• 1015445-53-0 {4-[4-(4-fluorophenyl)-3-methyl-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}-((R)-1-phenylethyl)amine 

Relevant academic research and scientific papers

Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR

The regiospecific synthesis of 2a (Scheme 3), a novel and potent pyridinyl imidazole inhibitor of p38 MAP (mitogen-activated protein) kinase, and the regioselective preparation of its regioisomer 2b (Scheme 4) are described. Chromatographic and spectroscopic data are presented, which in this class of compounds allow the unambiguous identification of regioisomers prepared by a nonregiospecific synthetic strategy. Biological data demonstrating the importance of the correct regiochemistry for inhibition of p38 are given.

Regiospecific and highly flexible synthesis of 1,4,5-trisubstituted 2-sulfanylimidazoles from structurally diverse ethanone precursors

Imidazoles represent important bioactive scaffolds in medicinal chemistry. More than 2,500 structures are listed in drug discovery databases and over 3,000 patents have been claimed for imidazole-based structures. Recent imidazole pharmacophores have targ