(R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline

Base Information

• Chemical Name: (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline
• CAS No.: 503112-33-2
• Molecular Formula: C₃₄H₂₁F₆IN₂O
• Molecular Weight: 714.448
• Mol file: 503112-33-2.mol

Synonyms:(R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline

Chemical Property of (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline

There total 4 articles about (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(4R,5R)-2-(2-iodophenyl)-4,5-bis-(4-trifluoromethylphenyl)-4,5-dihydro-1H-imidazole (503112-13-8) + 2-naphthaloyl chloride (2243-83-6) → (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline (503112-33-2)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ol0340179

Reference yield:

2-iodobenzimidate → (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline (503112-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ethanol / 3 h / Heating

2: 94 percent / DMAP / CH₂Cl₂ / 4 h / 20 °C

With dmap; In ethanol; dichloromethane;

DOI:10.1021/ol0340179

Reference yield:

o-iodobenzamide (3930-83-4) → (R,R)-iodo-N-2-naphthoyl-bis-(4-trifluoromethylphenyl) imidazoline (503112-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / CH₂Cl₂ / 20 °C

2: 70 percent / ethanol / 3 h / Heating

3: 94 percent / DMAP / CH₂Cl₂ / 4 h / 20 °C

With dmap; In ethanol; dichloromethane;

DOI:10.1021/ol0340179

upstream raw materials:

(4R,5R)-2-(2-iodophenyl)-4,5-bis-(4-trifluoromethylphenyl)-4,5-dihydro-1H-imidazole

2-naphthaloyl chloride

o-iodobenzamide

(R,R)-1,2-bis(4-trifluoromethylphenyl)-1,2-ethanediamine