3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

Base Information

Chemical Name:3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide
CAS No.:1307895-86-8
Molecular Formula:C₁₉H₁₄N₄O₂
Molecular Weight:330.346
Hs Code.:

Synonyms:3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

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Chemical Property of 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

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Technology Process of 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

There total 3 articles about 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1307896-55-4
3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)benzaldehyde

: 6330-25-2
N-methyl-2-cyanoacetamide

: 1307895-86-8
3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

Reference yield:

: 75650-38-3
3-formylbenzoyl chloride

: 1307895-86-8
3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.08 h / 20 °C

With aluminum (III) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;

Reference yield:

: 271-63-6
7-Azaindole

: 1307895-86-8
3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyano-N-methylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.08 h / 20 °C

With aluminum (III) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;