2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

Base Information

Chemical Name:2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid
CAS No.:1369957-86-7
Molecular Formula:C₂₄H₂₀ClFN₂O₇S
Molecular Weight:534.949
Hs Code.:

Synonyms:2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

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Chemical Property of 2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

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Technology Process of 2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

There total 5 articles about 2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369957-45-8
2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfanyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

: 1369957-86-7
2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 1849-36-1
para-nitrobenzenethiol

: 1369957-86-7
2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide; water / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 20 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / 1 h / 20 °C / Cooling with ice

With water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1369800-50-9
α-[(4-nitrophenyl)thio]-γ-butyrolactone

: 1369957-86-7
2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 2 h / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide; water / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

4.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / 1 h / 20 °C / Cooling with ice

With water; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;