N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide
CAS No.:135068-37-0
Molecular Formula:C₅₂H₆₇N₃O₈S
Molecular Weight:894.185
Hs Code.:

N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

Synonyms:N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

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Chemical Property of N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

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Technology Process of N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

There total 17 articles about N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5394-18-3
2-(4-bromobutyl)isoindoline-1,3-dione

: 135068-32-5
N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-4-methyl-benzenesulfonamide

: 135068-37-0
N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

: 19803-37-3
Tetrakis(benzyloxy)titanium

: 135068-37-0
N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 15 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

9: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂ / -60 °C

10: tetrahydrofuran

11: 93 percent / CSA

12: 86 percent / Na, C₁₀H₈ / tetrahydrofuran

13: 94 percent / K₂CO₃ / benzene; toluene; H₂O

14: 94 percent / LAH / tetrahydrofuran / Heating

15: 95 percent / K₂CO₃ / dimethylformamide

With lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; naphthalene; camphor-10-sulfonic acid; sodium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

: 89461-51-8
[(2S,3S)-3-pentyloxiran-2-yl]methanol

: 135068-37-0
N-{3-[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-2-(2,2-dimethoxy-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl}-N-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 15 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

9: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂ / -60 °C

10: tetrahydrofuran

11: 93 percent / CSA

12: 86 percent / Na, C₁₀H₈ / tetrahydrofuran

13: 94 percent / K₂CO₃ / benzene; toluene; H₂O

14: 94 percent / LAH / tetrahydrofuran / Heating

15: 95 percent / K₂CO₃ / dimethylformamide

With lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; naphthalene; camphor-10-sulfonic acid; sodium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4039(00)74295-X