5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

Base Information

Chemical Name:5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide
CAS No.:1253734-43-8
Molecular Formula:C₂₃H₂₃F₂N₇O₃S
Molecular Weight:515.544
Hs Code.:

Synonyms:5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

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Chemical Property of 5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

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Technology Process of 5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

There total 9 articles about 5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253733-81-1
5-(2,6-difluorophenyl)-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 1253734-43-8
5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; methanol; at 65 ℃; for 3h;

Reference yield:

: 1253733-68-4
3-(4-iodophenyl)-1H-pyrazol-4-ylamine

: 1253734-43-8
5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / dichloromethane / 3 h / 0 - 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: 0.17 h / Inert atmosphere

3.2: 1.5 h / 130 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

7.1: 1,4-dioxane / 0.17 h / Inert atmosphere

7.2: 4 h / Reflux

8.1: hydrogenchloride / 0.08 h / 100 °C / Microwave irradiation

8.2: pH 7

9.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran; methanol / 3 h / 65 °C

With pyridine; hydrogenchloride; phosphorus pentoxide; hydroxylamine hydrochloride; bromine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1253733-76-4
5-(2,6-difluorophenyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 1253734-43-8
5-(2,6-difluorophenyl)-N-hydroxy-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

3.1: 1,4-dioxane / 0.17 h / Inert atmosphere

3.2: 4 h / Reflux

4.1: hydrogenchloride / 0.08 h / 100 °C / Microwave irradiation

4.2: pH 7

5.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran; methanol / 3 h / 65 °C

With hydrogenchloride; hydroxylamine hydrochloride; bromine; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;