3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

Base Information

Chemical Name:3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile
CAS No.:1253733-78-6
Molecular Formula:C₂₃H₂₁BrF₂N₄OSi
Molecular Weight:515.432
Hs Code.:

Synonyms:3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

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Chemical Property of 3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

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Technology Process of 3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

There total 7 articles about 3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253733-77-5
3-bromo-5-(2,6-difluorophenyl)-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1253733-79-7
3-bromo-5-(2,6-difluorophenyl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 1253733-78-6
3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 18063-02-0
2,6-difluorobenzoylchloride

: 1253733-79-7
3-bromo-5-(2,6-difluorophenyl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 1253733-78-6
3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: 0.17 h / Inert atmosphere

3.2: 1.5 h / 130 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1253733-68-4
3-(4-iodophenyl)-1H-pyrazol-4-ylamine

: 1253733-79-7
3-bromo-5-(2,6-difluorophenyl)-2-{[2-(trimethylsilyl)ethoxy]methyl}-2H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 1253733-78-6
3-bromo-5-(2,6-difluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: 0.17 h / Inert atmosphere

3.2: 1.5 h / 130 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;