[N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine

Base Information

• Chemical Name: [N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine
• CAS No.: 1324007-53-5
• Molecular Formula: C₁₈H₂₃N₅O₃
• Molecular Weight: 357.412
• Mol file: 1324007-53-5.mol

Synonyms:[N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine

Chemical Property of [N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine

There total 1 articles about [N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

benzyl(methyl)carbamic chloride (32366-02-2) + tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate (152120-61-1) → [N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine (1324007-53-5)

Guidance literature:

tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate; With sodium hydride; In tetrahydrofuran; paraffin; at 0 - 20 ℃;

benzyl(methyl)carbamic chloride; In tetrahydrofuran; paraffin; for 1h; Reflux;

DOI:10.1016/j.tet.2011.05.073

Reference yield: 85.0%

[N-(tert-butoxycarbonyl)-N'-(N-benzylcarbamoyl-N-methyl)]-1H-pyrazole-1-carboxamidine (1324007-53-5) + C91H158N6O12 (1324007-48-8) → C106H177N9O15 (1324007-55-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/j.tet.2011.05.073

upstream raw materials:

benzyl(methyl)carbamic chloride

tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate

Downstream raw materials:

C₁₀₆H₁₇₇N₉O₁₅