2,6-Dichloroimidazo[1,5-A]pyrido[3,2-E]pyrazine

Base Information

• Chemical Name: 2,6-Dichloroimidazo[1,5-A]pyrido[3,2-E]pyrazine
• CAS No.: 240815-53-6
• Molecular Formula: C9H4 Cl2 N4
• Molecular Weight: 239.06
• DSSTox Substance ID: DTXSID00459852
• Mol file: 240815-53-6.mol

Synonyms:2,6-DICHLOROIMIDAZO[1,5-A]PYRIDO[3,2-E]PYRAZINE;240815-53-6;7,12-dichloro-2,4,8,13-tetrazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene;SCHEMBL4040875;DTXSID00459852;AB44520;CS-0491471;7, 12-dichloro-2, 4, 8, 13-tetrazatricyclo[7.4.0.02, 6]trideca-1(9), 3, 5, 7, 10, 12-hexaene

Chemical Property of 2,6-Dichloroimidazo[1,5-A]pyrido[3,2-E]pyrazine

Chemical Property:

• PKA: -0.66±0.50(Predicted)
• PSA: 43.08000
• Density: 1.76±0.1 g/cm3(Predicted)
• LogP: 2.58430
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 237.9813015
• Heavy Atom Count: 15
• Complexity: 252

Purity/Quality:

98%min ^*data from raw suppliers

2,6-DICHLOROIMIDAZO-[1,5-A]PYRIDO-[3,2-E]PYRAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC2=C1N=C(C3=CN=CN32)Cl)Cl

Technology Process of 2,6-Dichloroimidazo[1,5-A]pyrido[3,2-E]pyrazine

There total 4 articles about 2,6-Dichloroimidazo[1,5-A]pyrido[3,2-E]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-2,6-dichloropyridine (62476-56-6) → 2,6-dichloroimidazo[1,5-a]pyrido[3,2-e]pyrazine (240815-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / -10 °C

1.2: tetrahydrofuran / 20 °C

2.1: potassium carbonate / N,N-dimethyl-acetamide / Heating

3.1: phosphorus oxychloride / Heating

With sodium hexamethyldisilazane; potassium carbonate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1021/jm030217e

Reference yield:

3H-imidazole-4-carboxylic acid (2,6-dichloro-pyridin-3-yl)-amide (240815-51-4) → 2,6-dichloroimidazo[1,5-a]pyrido[3,2-e]pyrazine (240815-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-acetamide / Heating

2: phosphorus oxychloride / Heating

With potassium carbonate; trichlorophosphate; In N,N-dimethyl acetamide;

DOI:10.1021/jm030217e

Reference yield:

2-chloroimidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5H)-one (240815-52-5) → 2,6-dichloroimidazo[1,5-a]pyrido[3,2-e]pyrazine (240815-53-6)

Guidance literature:

With trichlorophosphate; Heating;

DOI:10.1021/jm030217e

upstream raw materials:

2-chloroimidazo[1,5-a]pyrido[3,2-e]pyrazin-6(5H)-one

3-amino-2,6-dichloropyridine

3H-imidazole-4-carboxylic acid (2,6-dichloro-pyridin-3-yl)-amide

Downstream raw materials:

2-Chloro-N-(2-chloro-6-methylphenyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine

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