N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide

Base Information

• Chemical Name: N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide
• CAS No.: 386768-88-3
• Molecular Formula: C₂₆H₂₈N₄O₄S
• Molecular Weight: 492.599
• Mol file: 386768-88-3.mol

Synonyms:N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide

Chemical Property of N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide

There total 8 articles about N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-(3-cyanobenzyl)-2-[(4-methyl-1-piperidinyl)carbonyl]hydrazinium chloride (439926-78-0) → N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide (386768-88-3)

Guidance literature:

Reference yield:

3-Cyanobenzaldehyde (24964-64-5) → N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide (386768-88-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ethanol / Heating

2.1: H₂ / Pd/C / methanol

3.1: CH₂Cl₂

3.2: DIEA / CH₂Cl₂

4.1: HCl (gas); AcOH

5.1: Et₃N / CH₂Cl₂

With hydrogenchloride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2003.12.083

Reference yield:

6-methoxy-naphthalene-2-sulfonyl chloride (56875-59-3) + 4-methyl-piperidine-1-carboxylic acid N-(3-cyano-benzyl)-hydrazide (439926-99-5) → N'-(3-cyanobenzyl)-6-methoxy-N-[(4-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide (386768-88-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

6-methoxy-naphthalene-2-sulfonyl chloride

4-methyl-piperidine-1-carboxylic acid N-(3-cyano-benzyl)-hydrazide

4-methylpiperidin

3-Cyanobenzaldehyde