56875-59-3

Basic information

• Product Name: 6-methoxy-2-naphthalenesulfonyl chloride(SALTDATA: FREE)
• Synonyms: 6-methoxy-2-naphthalenesulfonyl chloride(SALTDATA: FREE);6-Methoxynaphthalene-2-sulfonyl chloride
• CAS NO: 56875-59-3
• Molecular Formula: C₁₁H₉ClO₃S
• Molecular Weight: 256.70536
• Mol File: 56875-59-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-methoxy-2-naphthalenesulfonyl chloride(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methoxy-2-naphthalenesulfonyl chloride(SALTDATA: FREE)(56875-59-3)
• EPA Substance Registry System: 6-methoxy-2-naphthalenesulfonyl chloride(SALTDATA: FREE)(56875-59-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 56875-59-3(Hazardous Substances Data)

Usage

Uses

4-(3-Fluorophenyl)pyrimidin-2-amine can be used as inhibitors of NLRP3 inflammasome activation to treat diseases.

Upstream product

• 135-76-2 sodium 2-naphthol-6-sulfonate 
• 149353-39-9 sodium 6-methoxy-2-naphthalenesulfonate 
• 832-85-9 2-hydroxy-8-naphthalenesulfonic acid monosodium salt 

Downstream Products

• 1360630-60-9 6-methoxy-N-(3'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide 
• 1360630-54-1 N-(biphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide 
• 1360630-57-4 6-methoxy-N-(3'-(trifluoromethyl)biphenyl-4-yl)naphthalene-2-sulfonamide 
• 1360630-65-4 N-(3',4'-dimethoxybiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide 
• 1360630-61-0 6-methoxy-N-(3'-nitrobiphenyl-4-yl)naphthalene-2-sulfonamide 
• 1360630-63-2 methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-4-carboxylate 
• 1360630-59-6 N-(3'-chlorobiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide 
• 1360630-58-5 N-(3'-fluorobiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide 
• 1360630-64-3 6-methoxy-N-(4'-methoxybiphenyl-4-yl)naphthalene-2-sulfonamide 
• 1360630-66-5 N-(2,4'-dimethoxybiphenyl-4-yl)-6-methoxynaphthalene-2-sulfonamide 
• 1360630-56-3 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxamide 
• 1360630-55-2 methyl 4'-(6-methoxynaphthalene-2-sulfonamido)biphenyl-3-carboxylate 
• 439926-88-2 N'-(3-Cyanobenzyl)-6-methoxy-N'-[(2-methyl-1-piperidinyl)carbonyl]-2-naphthalenesulfonohydrazide 
• 439926-95-1 N'-(1-Azepanylcarbonyl)-N'-(3-cyanobenzyl)-6-methoxy-2-naphthalenesulfonohydrazide 

Relevant articles and documents

SULFONYLATED TETRAHYDROAZOLOPYRAZINES AND THEIR USE AS MEDICINAL PRODUCTS

The present invention relates to sulfonylated tetrahydroazolopyrazines, methods for the preparation thereof, medicinal products containing these compounds and the use of substituted indole compounds for the preparation of medicinal products (Formula I).

Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme

Mur ligases have essential roles in the biosynthesis of peptidoglycan, and they represent attractive targets for the design of novel antibacterials. MurD (UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase) is the second enzyme in the series of Mur ligases, and it catalyzes the addition of D-glutamic acid (D-Glu) to the cytoplasmic intermediate UDP-N-acetylmuramoyl-L-alanine (UMA). Because of the high binding affinity of D-Glu toward MurD, we synthesized and biochemically evaluated a series of N-substituted D-Glu derivatives as potential inhibitors of MurD from E. coli, which allowed us to explore the structure-activity relationships. The substituted naphthalene-N-sulfonyl-D-Glu inhibitors, which were synthesized as potential transitionstate analogues, displayed IC50 values ranging from 80 to 600 μM. In addition, the high-resolution crystal structures of MurD in complex with four novel inhibitors revealed details of the binding mode of the inhibitors within the active site of MurD. Structure-activity relationships and cocrystal structures constitute an excellent starting point for further development of novel MurD inhibitors of this structural class.

Bispiperidines as antithrombotic agents

Novel compounds which are inhibitors of the binding of fibrinogen to the Gp IIb/IIIa platelet receptors, and which can be used therepeutically as antithrombotic agents